Animal-Free Recombinant Human IGF-BP7
IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP7 is expressed in a wide range of normal human tissues and it generally shows reduced expression in cancer cell lines of prostate, breast, colon, and lung origin. It plays a role in skeletal myogenesis by binding to IGF in a manner that inhibits IGF induced differentiation of skeletal myoblasts, without affecting IGF induced proliferation. Additionally, IGF-BP7 suppresses growth and colony formation of prostate and breast cancer cell lines through an IGF independent mechanism, which causes a delay in the G1 phase of the cell cycle, and increased apoptosis. Recombinant human IGF-BP7 is a 26.4 kDa protein consisting of 256 amino acid residues. Manufactured using all non-animal reagents.
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
NULL
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Biological Activity
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Testing In Progress.
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AA Sequence
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SSSDTCGPC EPASCPPLP PLGCLLGET RDACGCCPM CARGEGEPC GGGGAGRGY CAPGMECVK SRKRRKGKA GAAAGGPGV SGVCVCKSR YPVCGSDGT TYPSGCQLR AASQRAESR GEKAITQVS KGTCEQGPS IVTPPKDIW NVTGAQVYL SCEVIGIPT PVLIWNKVK RGHYGVQRT ELLPGDRDN LAIQTRGGP EKHEVTGWV LVSPLSKED AGEYECHAS NSQGQASAS AKITVVDAL HEIPVKKGE GAEL
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| Research Interest: | , , Proliferation and Cell Cycle, |
| Protein Cross Reactivity: | NULL |