Animal-Free Recombinant Human IL-15
IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowel disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 114 amino acid residues. Manufactured using all non-animal reagents.
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Monkey, Mouse
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Biological Activity
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The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
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AA Sequence
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MNWVNVISD LKKIEDLIQ SMHIDATLY TESDVHPSC KVTAMKCFL LELQVISLE SGDASIHDT VENLIILAN NSLSSNGNV TESGCKECE ELEEKNIKE FLQSFVHIV QMFINTS
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| Research Interest: | , , , , , , Inflammation |
| Cell Type: | , |
| Protein Cross Reactivity: | Monkey, Mouse |