Recombinant Human BMP-4
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. The E.coli derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits which correspond to amino acids 303-408 of the full length BMP-4 precursor. LDN193191
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Mouse
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Biological Activity
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Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml.
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AA Sequence
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KKNKNCRRH SLYVDFSDV GWNDWIVAP PGYQAFYCH GDCPFPLAD HLNSTNHAI VQTLVNSVN SSIPKACCV PTELSAISM LYLDEYDKV VLKNYQEMV VEGCGCR
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| Research Interest: | , , , , Proliferation and Cell Cycle |
| Protein Cross Reactivity: | Mouse |