Recombinant Human VEGF 121

VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF₁₂₁ circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant human VEGF₁₂₁ is a 28.4 kDa disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains. Dasatinib