Recombinant Human VEGF-B
VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains. (+)-JQ-4
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
NULL
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Biological Activity
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Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) in the presence of human VEGF165. The expected ED50 for this effect is 1.0-2.0 μg/ml.
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AA Sequence
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PVSQPDAPG HQRKVVSWI DVYTRATCQ PREVVVPLT VELMGTVAK QLVPSCVTV QRCGGCCPD DGLECVPTG QHQVRMQIL MIRYPSSQL GEMSLEEHS QCECRPKKK DSAVKPDSP RPLCPRCTQ HHQRPDPRT CRCRCRRRS FLRCQGRGL ELNPDTCRC RKLRR
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| Research Interest: | , , Inflammation, Proliferation and Cell Cycle |
| Cell Type: | Endothelial Cells, Neurons |
| Protein Cross Reactivity: | NULL |