Recombinant Human sTNF Receptor Type II
TNFRII is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF-α but manifests a lower affinity to TNF-β. Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. Soluble TNFRII is capable of inhibiting TNF-α induced activities by acting as a decoy receptor. Recombinant human sTNFRII is an 18.9 kDa protein (174 amino acid residues) comprising the cysteine rich ligand binding portion of the extracellular domain of the TNFRII protein. Vemurafenib
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Mouse
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Biological Activity
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Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-α, is 0.125 µg/ml.
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AA Sequence
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MAPEPGSTC RLREYYDQT AQMCCSKCS PGQHAKVFC TKTSDTVCD SCEDSTYTQ LWNWVPECL SCGSRCSSD QVETQACTR EQNRICTCR PGWYCALSK QEGCRLCAP LRKCRPGFG VARPGTETS DVVCKPCAP GTFSNTTSS TDICRPHQI CNVVAIPGN ASMDAVCTS TSP
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| Research Interest: | , , , Inflammation, Proliferation and Cell Cycle |
| Cell Type: | Endothelial Cells |
| Protein Cross Reactivity: | Mouse |