In this study we effectively solved the problem of conjugative transfer of the GE2270 biosynthetic gene cluster into Streptomycetes, allowing for the very first time heterologous creation of GE2270 in a Streptomyces pressure

We thereby demonstrated that genes belonging to primary metabolism of phylogenetic distant donor species may avert conjugal transfer of the wanted biosynthetic gene cluster. Our 1st try to obtain heterologous…