Anti-Mouse CD154 (CD40 Ligand) Biotin
The MR1 monoclonal antibody specifically reacts with mouse CD154, a 39kDA transmembrane glycoprotein also known as CD40 ligand and gp39. CD154 is expressed on activated T cells and plays a role in B-T cell costimulation. The interaction of CD154 with CD40 induces B cell cycle entry and the signaling for T-dependent B cell activation. By interfering with this interaction, the MR1 antibody is reported to inhibit T and B lymphocyte activation. LY2606369 (dihydrochloride)
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Clone
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MR1
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Format: |
Biotin
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Applications
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FC
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Reactivity
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Mouse
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Isotype:
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Armenian Hamster IgG
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Noelle, R. J., Roy, M., Shepherd, D. M., Stamenkovic, I., Ledbetter, J. A., & Aruffo, A. (1992). A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proceedings of the National Academy of Sciences, 89(14), 6550-6554. Roy, M., Aruffo, A., Ledbetter, J., Linsley, P., Kehry, M., & Noelle, R. (1995). Studies on the interdependence of gp39 and B7 expression and function during antigen‐specific immune responses. European journal of immunology, 25(2), 596-603. Van den Eertwegh, A. J., Noelle, R. J., Roy, M. E. E. N. A. K. S. H. I., Shepherd, D. M., Aruffo, A., Ledbetter, J. A., … & Claassen, E. (1993). In vivo CD40-gp39 interactions are essential for thymus-dependent humoral immunity. I. In vivo expression of CD40 ligand, cytokines, and antibody production delineates sites of cognate TB cell interactions. The Journal of experimental medicine, 178(5), 1555-1565. |