Recombinant Human IGF-BP3
IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues. Enzalutamide
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
NULL
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Biological Activity
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The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is ≤ 0.2 µg/ml in presence of 15 ng/ml of human IGF-II.
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AA Sequence
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GASSGGLGP VVRCEPCDA RALAQCAPP PAVCAELVR EPGCGCCLT CALSEGQPC GIYTERCGS GLRCQPSPD EARPLQALL DGRGLCVNA SAVSRLRAY LLPAPPAPG NASESEEDR SAGEVESPS VSSTHRVSD PKFHPLHSK IIIIKKGHA KDSQRYKVD YESQSTDTQ NFSSESKRE TEYGPCRRE MEDTLNHLK FLNVLSPRG VHIPNCDKK GFYKKKQCR PSKGRKRGF CWCVDKYGQ PLPGYTTKG KEDVHCYSM QSK
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| Research Interest: | , , Proliferation and Cell Cycle, |
| Protein Cross Reactivity: | NULL |