IL-12 Protein

Description:
|Introduction IL-12 is a heterodimeric cytokine that stimulates the production of interferon gamma from T-cells and natural killer cells, and also induces differentiation of Th1 helper cells. IL-12 is an initiator of cell-mediated immunity. |Reco|E. coli-derived. A glycosylated disulfide linked heterodimeric polypeptide containing 503 amino acids and having a molecular weight of 70 kDa comprised of disulfide-bonded 35 kDa (p35) and 40 kDa (p40) subunits. ED50 range = 0.01-0.05 ug/ml corresponding to a specific activity of 20-100 MIU/mg as determined by the dose dependent secretion of interferon-gamma from PHA and IL-2 activated mouse splenocytes that have been costimulated with PMA. Optimal concentration for individual application should be determined by a dose response assay. Purity > 95%, by SDS-|The protein (1 ug/ml) was lyophilized with no additives. Reconstitution: It is recommended to reconstitute the lyophilized Interleukin 12 in sterile 18 M?-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Shipping: The product is shipped at a|Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution. |Other IL-12 Proteins: Reco|IL-12β Monoclonal Antibody IL-12p75 Monoclonal Antibody IL-12p40 Monoclonal Antibody IL-12 Polyclonal Antibody