Ne content with the AD group was larger than that on the cascular dementia group (Figure ).Discussion Homocysteine is definitely an intermediate solution of methionine metabolism.Several studies showed that homocysteine was an independent risk aspect for coronary artery disease, cerebrovascular illness, peripheral vascular illness and other folks.Some studies held that hyperhomocysteinemia played a role within the occurrence and improvement of AD.Research have shown that high homocysteine brought on Sodium lauryl polyoxyethylene ether sulfate Epigenetic Reader Domain cognitive function and resulted in AD, which may be associated with biochemical harm triggered by oxidative anxiety .High levels of homocysteine can markedly increase the content of oxygen free radicals and promote the formation of nitric oxide.Higher levels of nitric oxide can develop into neurotoxic substances .Oxygen absolutely free radicals can promote schizolysis of APP ( amyloid protein precursor) and formation of A amyloid protein, as a result escalating the generation and deposition of A, which can be the main pathological change in AD.Our study outcome showed that when the AD group was compared using the standard manage group, the MMSE score was lower and the homocysteine content material greater, with a statistically important difference among the two groups (P ).When the AD group was compared with the vascular dementia group, the MMSE scores were not drastically diverse between the two groups (P ); the homocysteine content material with the AD group was lower than that with the vascular dementia group, with a statistically important distinction (P ).Based on the comprehensive outcome from the above documents, it was frequently regarded as that the MMSE score and homocysteine content may be used as a single with the PubMed ID:http://www.ncbi.nlm.nih.gov/pubmed/21593114 indicators to distinguish AD and typical elderly subjects, plus the homocysteine content material as one on the indicators to distinguish AD and vascular dementia.The outcome of our metaanalysis was restricted inside the following elements firstly, though our study incorporated publications, we did not make stratified evaluation on gender and distinctive ages, so we couldn’t see far more detailed outcome; secondly, there existed selection bias that could not be excluded and also the influence of confounding elements that could not be determined; furthermore, there existed methodological defects in publications included in our metaanalysis, such as not clearly explaining random system, blinding process and other folks, which affected our analysis outcomes.It’s held in evidencebased medicine that the proof obtained from randomized controlled clinical trials has the strongest authenticity and reliability; and the extensive conclusion is far more convincing from systematic evaluation on numerous RCT and metaanalysis, as compared with single RCT.Most studies integrated in our analysis are retrospective casecontrol studies and don’t belong for the RCT category in the strict sense, which directly affects the demonstration strength of our metaanalysis outcome.Within the future, when generating systematic evaluation on multicenter RCT research among elderly people, we are hopeful to obtain conclusive evidence around the relationship in cognitive function in between homocysteine and AD, then offering directions to clinical practice and producing clinical intervention method more rational.Disclosure of conflict of interest None.Address correspondence to Dr.Yuan Zhong, Department of Geriatrics, Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Yishan Road, Shanghai , China.Tel ; E mail [email protected]
ORIGINAL Analysis Report Victimisation and PT.