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“Autotaxin (ectonucleotide pyrophosphatase/phosphodiesterase 2, NPP2, ENPP2) is a secreted enzyme essential for generating the lipid signaling molecule lysophosphatidic acid (LPA). Autotaxin has lysophospholipase D action that converts lysophosphatidylcholine into LPA. Autotaxin was originally identified as a tumor cell-motility-stimulating issue later it was proven to be LPA (which signals by way of Lysophospholipid receptors), the lipid item of the response catalyzed by autotaxin, which is liable for its effects on mobile-proliferation. The protein encoded by this gene functions as both equally a phosphodiesterase, which cleaves phosphodiester bonds at the 5′ end of oligonucleotides, and as a phospholipase, which catalyzes creation of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes development aspect-like responses including stimulation of cell proliferation and chemotaxis. This gene solution stimulates the motility of tumor cells, has angiogenic attributes, and its expression is upregulated in a number of varieties of carcinomas. The gene product or service is secreted and even more processed to make the biologically active form. A number of alternatively spliced transcript variants have been discovered, but the entire-duration nature of only two transcript variants has been determined.
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