Name : IL-2 R α, His, Human
Product Concentration :
Background :
Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to the cytokine IL-2. The IL-2R is made up of 3 subunits – alpha (α), beta (β) and gamma (γ). The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. The β and γ chains of the IL-2R are members of the type I cytokine receptor family. IL-2R has a high binding affinity to IL-2 and is expressed by antigen-activated T lymphocytes (T cells). IL-2 Rα is also known as CD25, p55, and Tac (activated T cell) antigen.
Biological Activity :
Determined by its ability to increase the proliferation effect of IL-2 in murine CTLL-2 cells. In the presence of 1.0 ng/ml of recombinant IL-2, ED50 for this effect is
expression system :
HEK 293
Tag :
Poly-His IL-2 Rα (Glu22-Cys213)Accession # P01589 N-term C-term
Protein Accession No. :
P01589
Synonyms :
IL2RA; soluble IL-2 receptor; TAC-antigen; CD25 antigen; Tac antigen; IL-2Rα
Molecular Weight :
~42 kDa, on SDS-PAGE under reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized after extensive dialysis against PBS.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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