Animal-Free Recombinant Human IL-13
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. Recombinant human IL-13 is a 12.6 kDa protein consisting of 115 amino acid residues. Manufactured using all non-animal reagents.
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Mouse
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Biological Activity
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The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
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AA Sequence
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MSPGPVPPS TALRELIEE LVNITQNQK APLCNGSMV WSINLTAGM YCAALESLI NVSGCSAIE KTQRMLSGF CPHKVSAGQ FSSLHVRDT KIEVAQFVK DLLLHLKKL FREGRFN
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| Research Interest: | , , , , , Inflammation |
| Cell Type: | , |
| Protein Cross Reactivity: | Mouse |