Animal-Free Recombinant Human IL-17 (IL-17A)
The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.3 kDa disulfide-linked homodimer of two 137 amino acid polypeptide chains. Manufactured using all non-animal reagents.
|
Source: |
E. Coli
|
|   | |
|
Purity:
|
Above 98% as determined by SDS-PAGE Analysis.
|
|   | |
|
Cross Reactivity: |
Mouse
|
|   | |
|
Biological Activity
|
Assay #1: The ED50 as determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblasts was found to be approximately 2 ng/ml.
Assay #2: Measured by its ability to |
|   | |
|
AA Sequence
|
MIVKAGITI PRNPGCPNS EDKNFPRTV MVNLNIHNR NTNTNPKRS SDYYNRSTS PWNLHRNED PERYPSVIW EAKCRHLGC INADGNVDY HMNSVPIQQ EILVLRREP PHCPNSFRL EKILVSVGC TCVTPIVHH VA
|
| Research Interest: | , Inflammation |
| Protein Cross Reactivity: | Mouse |