Animal-Free Recombinant Human IL -22
IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains. Manufactured using all non-animal reagents.
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
NULL
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Biological Activity
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Assay #1: Determined by its ability to activate STAT following receptor ligand interaction.
Assay #2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED |
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AA Sequence
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MAPISSHCR LDKSNFQQP YITNRTFML AKEASLADN NTDVRLIGE KLFHGVSMS ERCYLMKQV LNFTLEEVL FPQSDRFQP YMQEVVPFL ARLSNRLST CHIEGDDLH IQRNVQKLK DTVKKLGES GEIKAIGEL DLLFMSLRN ACI
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| Research Interest: | , |
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| Protein Cross Reactivity: | NULL |