Animal-Free Recombinant Human NT-3
NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous systems and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant human NT-3 is a noncovalently linked homodimer, of two 13.6 kDa polypeptide monomers (240 total amino acid residues). Human and Mouse NT-3 sequences are identical. Manufactured using all non-animal reagents.
|
Source: |
E. Coli
|
|   | |
|
Purity:
|
Above 98% as determined by SDS-PAGE Analysis.
|
|   | |
|
Cross Reactivity: |
Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat
|
|   | |
|
Biological Activity
|
The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml.
|
|   | |
|
AA Sequence
|
MYAEHKSHR GEYSVCDSE SLWVTDKSS AIDIRGHQV TVLGEIKTG NSPVKQYFY ETRCKEARP VKNGCRGID DKHWNSQCK TSQTYVRAL TSENNKLVG WRWIRIDTS CVCALSRKI GRT
|
| Research Interest: | , |
| Cell Type: | Neurons |
| Protein Cross Reactivity: | Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat |