Animal-Free Recombinant Murine GM-CSF
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant murine GM-CSF is a 14.2 kDa globular protein consisting of 125 amino acid residues. Manufactured using all non-animal reagents.
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Rat
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Biological Activity
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The ED50 as determined by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
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AA Sequence
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MAPTRSPIT VTRPWKHVE AIKEALNLL DDMPVTLNE EVEVVSNEF SFKKLTCVQ TRLKIFEQG LRGNFTKLK GALNMTASY YQTYCPPTP ETDCETQVT TYADFIDSL KTFLTDIPF ECKKPVQK
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| Research Interest: | , , , Inflammation, Proliferation and Cell Cycle |
| Cell Type: | , , , Endothelial Cells |
| Protein Cross Reactivity: | Rat |