Animal-Free Recombinant Rat GM-CSF
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues. Manufactured using all non-animal reagents.
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Mouse
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Biological Activity
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The ED50 was determined by the dose-dependent stimulation of the proliferation of Murine FDC-P1 cells is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1.0 x 108 units/mg.
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AA Sequence
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MAPTRSPNP VTRPWKHVD AIKEALSLL NDMRALENE KNEDVDIIS NEFSIQRPT CVQTRLKLY KQGLRGNLT KLNGALTMI ASHYQTNCP PTPETDCEI EVTTFEDFI KNLKGFLFD IPFDCWKPV QK
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| Research Interest: | , , , Inflammation, Proliferation and Cell Cycle |
| Cell Type: | , , Endothelial Cells |
| Protein Cross Reactivity: | Mouse |