Anti-Human CD51/CD61 (Integrin alpha v beta 3) SAFIRE Purified
The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor. The complex binds to other ligands such as CD29, fibrinogen, fibrinectin, vWf, laminin, and thrombospondin. It is expressed by endothelial cells, osteoclasts, melanoma cells, and at low levels on platelets and macrophages. The 23C6 antibody is reported to be able to block the receptors ability to form interactions with some of its ligands. ST 2827
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Clone
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23C6
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Human
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | , |
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Horton, M. A., Lewis, D., McNulty, K., Pringle, J. A., & Chambers, T. J. (1985). Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. Cancer research, 45(11 Part 2), 5663-5669. Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989. Chuntharapai, A., Bodary, S., Horton, M., & Kim, K. J. (1993). Blocking monoclonal antibodies to αvβ3 integrin: A unique epitope of αvβ3 integrin is present on human osteoclasts. Experimental cell research, 205(2), 345-352. |