Anti-Human CD59 (Protectin) PE
The OV9A2 monoclonal antibody specifically reacts with human CD59 (Protectin), a 19-25 kDA GPI-anchored glycoprotein. CD59 is expressed on hematopoietic and non-hematopoietic cells including lymphocytes, granulocytes, erythrocytes, monocytes and neurons. CD59 can inhibit complement cytolytic activity and the assembly of the membrane attack complex when bound to C8 and C9 complement components. It is involved in T cell activation and modulates T cell adhesion through interaction with CD2. INCB 024362
|
Clone
|
OV9A2
|
|
Format: |
PE
|
|
Applications
|
FC
|
|
Reactivity
|
Human
|
|
Isotype:
|
Mouse IgG1, kappa
|
| Research Interest: | , |
| Cell Type: | , , |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
Deckert, M., Kubar, J., Zoccola, D., Bernard‐Pomier, G., Angelisova, P., Horejsi, V., & Bernard, A. (1992). CD59 molecule: a second ligand for CD2 in T cell adhesion. European journal of immunology, 22(11), 2943-2947. Korty, P. E., Brando, C. L. A. R. A., & Shevach, E. M. (1991). CD59 functions as a signal-transducing molecule for human T cell activation. The Journal of immunology, 146(12), 4092-4098. Davies, A., Simmons, D. L., Hale, G., Harrison, R. A., Tighe, H., Lachmann, P. J., & Waldmann, H. (1989). CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. The Journal of experimental medicine, 170(3), 637-654. |