Anti-Human/Mouse CD146 PE
The P1H12 monoclonal antibody reacts with CD146, 118kDA transmembrane glycoprotein that is also called the melanoma cell adhesion molecule (Mel-CAM), MUC18, Endo-CAM, and S-Endo. It is a prominently glycosylated protein with carbohydrates comprising the majority of its mass and it is expressed on melanoma, stromal, endothelial, and bone marrow fibroblasts. The P1H12 antibody cross reacts with human, mouse, canine, rabbit to the exclusion of rat protein. Trametinib
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Clone
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P1H12
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Format: |
PE
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Applications
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FC
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Reactivity
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Human, Mouse
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Isotype:
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Mouse IgG1, kappa
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Elshal, M. F., Khan, S. S., Takahashi, Y., Solomon, M. A., & McCoy, J. P. (2005). CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood. Blood,106(8), 2923-2924. Shih, I. M. (1999). The role of CD146 (Mel‐CAM) in biology and pathology. The Journal of pathology, 189(1), 4-11. Solovey, A. N., Gui, L., Chang, L., Enenstein, J., Browne, P. V., & Hebbel, R. P. (2001). Identification and functional assessment of endothelial P1H12.Journal of Laboratory and Clinical Medicine, 138(5), 322-331. |