Anti-Human Perforin PE
The dG9 monoclonal antibody specifically reacts with human perforin, a cytolytic mediator found in the cytoplasmic granules of cytotoxic T (CTL) and natural killer (NK) cells. Perforin is integral molecule in targeted cell lysis and utilized in the immune system’s reaction to tumors and virus infections. BAY 80-6948
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Clone
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dG9 (delta G9)
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Format: |
PE
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Applications
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FC
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Reactivity
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Human
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Isotype:
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IgG2b, kappa
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Preperation:
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The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
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Formulation:
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Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
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References:
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Hameed, A., Olsen, K. J., Cheng, L., Fox 3rd, W. M., Hruban, R. H., & Podack, E. R. (1992). Immunohistochemical identification of cytotoxic lymphocytes using human perforin monoclonal antibody. The American journal of pathology, 140(5), 1025. Schlesinger, B. C., & Cheng, L. (1994). Characterization of a novel monoclonal antibody against human perforin using transfected cell lines. Immunology, 81(2), 291. Wood, S. M., Meeths, M., Chiang, S. C., Bechensteen, A. G., Boelens, J. J., Heilmann, C., … & Bryceson, Y. T. (2009). Different NK cell–activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity. Blood, 114(19), 4117-4127. |