Anti-Mouse CD30 SAFIRE Purified
The mCD301 monoclonal antibody specifically binds to mouse CD30, a member of the Tumor Necrosis Factor Receptor (TNFR) superfamily. It is expressed on activated T, B, NK, and monocyte cells. Its expression on activated T lymphocytes is regulated by cytokines and CD28. The ligand for CD30 is CD153. It has been suggested that the molecule plays a role in the protection against autoimmunity and the regulation of Th1 and Th2 cytokine secretion. Grapiprant
|
Clone
|
mCD30.1
|
|
Format: |
SAFIRE Purified
|
|
Applications
|
FC, FA
|
|
Reactivity
|
Mouse
|
|
Isotype:
|
Armenian Hamster IgG
|
| Research Interest: | |
| Cell Type: | , , , |
|
Preperation:
|
The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ph7.2.
|
|
References:
|
Siegmund, T., Armitage, N., Wicker, L. S., Peterson, L. B., Todd, J. A., & Lyons, P. A. (2000). Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9. 2. Diabetes, 49(9), 1612-1616. Falini, B., Pileri, S., Pizzolo, G., Dürkop, H., Flenghi, L., Stirpe, F., … & Stein, H. (1995). CD30 (Ki-1) molecule: a new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy. BLOOD-NEW YORK-, 85, 1-1. Heath, W. R., Kurts, C., Caminschi, I., Carbone, F. R., & Miller, J. F. (1999). CD 30 prevents T‐cell responses to non‐lymphoid tissues. Immunological reviews, 169(1), 23-29.
|