Anti-Mouse Notch3 APC
The HMN3-133 monoclonal antibody specifically reacts with mouse Notch3, a single-pass transmembrane protein. After binding with its ligand, Notch3 receptor undergoes cleavage resulting in a Notch intracellular domain (NICD) molecule that eventually activates transcription in the nucleus. It is expressed on Treg cells and adult smooth muscle arterial cells. TGR-1203
|
Clone
|
HMN3-133
|
|
Format: |
APC
|
|
Applications
|
FC
|
|
Reactivity
|
Mouse
|
|
Isotype:
|
Armenian Hamster IgG
|
| Research Interest: | |
| Cell Type: | , , |
|
Preperation:
|
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
|
|
Formulation:
|
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
|
|
References:
|
Moriyama, Y., Sekine, C., Koyanagi, A., Koyama, N., Ogata, H., Chiba, S., … & Yagita, H. (2008). Delta-like 1 is essential for the maintenance of marginal zone B cells in normal mice but not in autoimmune mice. International immunology, 20(6), 763-773. Bellavia, D., Checquolo, S., Campese, A. F., Felli, M. P., Gulino, A., & Screpanti, I. (2008). Notch3: from subtle structural differences to functional diversity. Oncogene, 27(38), 5092-5098. Shi, J., Fallahi, M., Luo, J. L., & Petrie, H. T. (2011). Nonoverlapping functions for Notch1 and Notch3 during murine steady-state thymic lymphopoiesis.Blood, 118(9), 2511-2519. |