Anti-Rat CD8b SAFIRE Purified
The 341 monoclonal antibody specifically reacts with the beta chain of the Rat CD8 molecule. The alpha and beta chains of the CD8 molecule form a heterodimer common on most thymocytes. The CD8 positive T cells of athymic rats and most NK cells express a homodimer composed solely of CD8a. It is reported that macrophages express CD8 alpha and beta chains for signal transduction. CD8 is an antigen co-receptor that interacts with MHC class I molecules on antigen-presenting cells. Integrin Antagonist 2 (hydrochloride)
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Clone
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341
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Format: |
SAFIRE Purified
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Applications
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FC, FA
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Reactivity
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Rat
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Isotype:
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Mouse IgG1, kappa
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| Research Interest: | |
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Preperation:
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The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
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Formulation:
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Phosphate-buffered aqueous solution, ph7.2.
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References:
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Hirji, N., Lin, T. J., Bissonnette, E., Belosevic, M., & Befus, A. D. (1998). Mechanisms of macrophage stimulation through CD8: macrophage CD8α and CD8β induce nitric oxide production and associated killing of the parasite Leishmania major. The Journal of Immunology, 160(12), 6004-6011. Hirji, N., Lin, T. J., & Befus, A. D. (1997). A novel CD8 molecule expressed by alveolar and peritoneal macrophages stimulates nitric oxide production. The Journal of Immunology, 158(4), 1833-1840. Torres‐Nagel, N., Kraus, E., Brown, M. H., Tiefenthaler, G., Mitnacht, R., Williams, A. F., & Hünig, T. (1992). Differential thymus dependence of rat CD8 isoform expression. European journal of immunology, 22(11), 2841-2848. |