Recombinant Human CDNF
CDNF is a secreted neurotrophic factor that is expressed in brain, neuronal and certain non-neuronal tissues. It has been shown to promote survival, growth and function of dopamine specific neurons. CDNF and its structural homolog MANF, each contain an N-terminal saposin-like lipid binding domain, and a carboxyl-terminal domain, which is not homologous to previously characterized protein structures. CDNF and MANF can prevent 6-OHDA induced degeneration of dopaminergic neurons by triggering survival pathways in a rat experimental model of Parkinson disease. Recombinant human CDNF is an 18.5 kDa protein consisting of 162 amino acids including 8 cysteine residues. XMU-MP-4
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
NULL
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Biological Activity
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Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 15-25 μg/ml.
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AA Sequence
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MQEAGGRPG ADCEVCKEF LNRFYKSLI DRGVNFSLD TIEKELISF CLDTKGKEN RLCYYLGAT KDAATKILS EVTRPMSVH MPAMKICEK LKKLDSQIC ELKYEKTLD LASVDLRKM RVAELKQIL HSWGEECRA CAEKTDYVN LIQELAPKY AATHPKTEL
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| Research Interest: | |
| Cell Type: | Neurons |
| Protein Cross Reactivity: | NULL |