Recombinant Human CNTF
CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant human CNTF is synthesized as a 199 amino acid polypeptide (22.8 kDa) lacking a hydrophobic N-terminal signal for secretion. PI-106 (Hydrochloride)
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Hamster, Mouse, Rat
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Biological Activity
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Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml.
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AA Sequence
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AFTEHSPLT PHRRDLCSR SIWLARKIR SDLTALTQS YVKHQGLNK NINLDSADG MPVASTDQW SQLTQAQRL QQNLQAYRT FHVLLARLL QDQQVHFTP TQGDFHQAI HTLLLQVAA FAYQIQQLM ILLQYKIPR NQADGMPIN VGDGGLFQK KLWGLKVLQ QLSQWTVRS IHDLRFISS HQTGIPARG SHYIANNKK M
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| Research Interest: | , , , , , Inflammation, |
| Cell Type: | , Neurons |
| Protein Cross Reactivity: | Hamster, Mouse, Rat |