Recombinant Human VEGF 165
VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant human VEGF165 is a 38.2 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains. GNE-497
|
Source: |
E. Coli
|
|   | |
|
Purity:
|
Above 98% as determined by SDS-PAGE Analysis.
|
|   | |
|
Cross Reactivity: |
Cow, Guinea Pig, Hamster, Mouse, Pig, Rabbit, Rat, Sheep, Trout
|
|   | |
|
Biological Activity
|
Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 1.0-8.0 ng/ml.
|
|   | |
|
AA Sequence
|
APMAEGGGQ NHHEVVKFM DVYQRSYCH PIETLVDIF QEYPDEIEY IFKPSCVPL MRCGGCCND EGLECVPTE ESNITMQIM RIKPHQGQH IGEMSFLQH NKCECRPKK DRARQENPC GPCSERRKH LFVQDPQTC KCSCKNTDS RCKARQLEL NERTCRCDK PRR
|
| Research Interest: | , , , Inflammation, Proliferation and Cell Cycle |
| Cell Type: | , |
| Protein Cross Reactivity: | Cow, Guinea Pig, Hamster, Mouse, Pig, Rabbit, Rat, Sheep, Trout |