Recombinant Human sTRAIL/Apo2L
TRAIL/Apo2L is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic “death domain”, which activates the cells apoptotic machinery. Recombinant human soluble TRAIL/Apo2L is a 168 amino acid polypeptide (19.6 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL/Apo2L protein. Senicapoc
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Mouse
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Biological Activity
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Assay#1:Determined by its ability to induce apoptotic cell death in TRAIL-sensitive U343MG cells. The expected ED50 for this effect is 1.0-3.0 ng/ml.
Assay#2:Measured by its abili |
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AA Sequence
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MRERGPQRV AAHITGTRG RSNTLSSPN SKNEKALGR KINSWESSR SGHSFLSNL HLRNGELVI HEKGFYYIY SQTYFRFQE EIKENTKND KQMVQYIYK YTSYPDPIL LMKSARNSC WSKDAEYGL YSIYQGGIF ELKENDRIF VSVTNEHLI DMDHEASFF GAFLVG
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| Research Interest: | |
| Protein Cross Reactivity: | Mouse |