Recombinant Rat CNTF
CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant rat CNTF is synthesized as a 199 amino acid polypeptide (22.7 kDa) lacking a hydrophobic N-terminal signal for secretion. TRO 19625
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Source: |
E. Coli
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Purity:
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Above 98% as determined by SDS-PAGE Analysis.
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Cross Reactivity: |
Frog, Human, Mouse
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Biological Activity
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Determined by its ability to stimulate proliferation of human TF-1 cells using a concentration range of 25.0-35.0 ng/ml.
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AA Sequence
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AFAEQTPLT LHRRDLCSR SIWLARKIR SDLTALMES YVKHQGLNK NINLDSVDG VPVASTDRW SEMTEAERL QENLQAYRT FQGMLTKLL EDQRVHFTP TEGDFHQAI HTLMLQVSA FAYQLEELM VLLEQKIPE NEADGMPAT VGDGGLFEK KLWGLKVLQ ELSQWTVRS IHDLRVISS HQMGISALE SHYGAKDKQ M
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| Research Interest: | , , , , , Inflammation, |
| Cell Type: | , Neurons |
| Protein Cross Reactivity: | Frog, Human, Mouse |