He Greek words “helios” which means “sun” and “tropein” meaning “to turn,” indicating that the flowers and leaves turn toward the sun and generally known as the “Indian turnsole” [6]. It truly is also known as AMPA Receptor manufacturer Eliopia riparia Raf., Eliopia serrata Raf., Heliophytum indicum (L.) DC., Heliotropium africanum Schumach. onn., Heliotropium cordifolium Moench, Heliotropium foetidum Salisb., Heliotropium horminifolium Mill., and Tiaridium indicum (L.) Lehm. H. indicum is distributed throughout Bangladesh, Nepal, Sri Lanka, ailand, India, along with other locations of tropical Asia and in some parts of Africa [7]. H. indicum can be a modest annual or perennial herb with a height of about 150 cm in length, using the leaves normally opposite, plus the stem and root covered by a hairy layer [7]. Flowering time is about the entire year, and flowers are calyx green; the fruits are dried and consist of two free of charge or just about free of charge nutlets in four mm long [8]. Traditionally, this plant is broadly utilized against several pathological problems which includes wound healing, antidote, bone fracture, febrifuge, cures eye infection, menstrual disorder, nerve disorder, kidney difficulty, and antiseptic goal [94]. H. indicum consists of quite a few significant phytochemicals for instance tannins, saponins, steroids, oils, and glycosides [12,15]. Schoental [16] and Hartmann and Ober [17] isolated pyrrolizidine alkaloids (e.g., indicine N-oxide, heliotrine, and so forth.) from this plant. Scientific reports suggest that H. indicum possesses a lot of significant pharmacological activities, like antiinflammatory [18], wound-healing [19], anticancer [15], and anticataract activities [20]. is critique aims to show the present scenario around the ethnomedicinal, phytochemical, and pharmacological profiles of H. indicum.three. Plant MorphologyH. indicum is definitely an erect, thick fetid, annual or perennial herb with hirsute ascending branches, reaching amongst 20 and 60 cm in height [13]. e leaves are opposite or sub-opposite, alternate or sub-alternate and straight forward, sheet-shaped from ovate to elliptical, hairy, and sharp and 50 cm long. e margins of the leaves are undulate; the nerves present on each sides are serrulate or cordate and clearly visible below the leaves [21]. e petiole is about 1 cm lengthy, although the flowers progress apically within the cymose; at maturity, nutlets are present in the base from the inflorescence. Typically, flowers are white or whitish violet in colour, frequent, sessile, axillary, and almost 5 mm in diameter. Sepals are diffused with hairs outdoors, deep green in color, linear to lanceolate, uneven or unequal, and about five mm lengthy. e fruits are dry and two lobed, with or without having united nutlets, and three mm extended. is species grows in sunny locations preferring heights around 800 m [22]. Botanical descriptions of H. indicum are provided in Table 1.four. Methodologye literature search was performed making use of the databases: Google Scholar, Scopus, SpringerLink, Net of Science, ScienceDirect, ResearchGate, PubMed, ChemSpider, Elsevier, BioMed Central, and USPTO, CIPO, INPI, Google Patents, and Espacenet. e scientific databases have been selected depending on the topic covered (i.e., ethnobotany, ethnomedicinal uses, ethnopharmacology, pharmacology, phytochemistry, and therapeutic worth) and geographical coverage (i.e., Asia and Africa). e popular keyword “Heliotropium indicum” was utilized to search published components, which was then paired with “traditional uses,” “ethnopharmacology,” “phytochemistry,” “pharmacology,” and “Caspase 8 web toxicity.” Other literature sources incorporated papers p.