ary embolism remains high and could be exhibiting an growing trend in some low- and middle-income countries. Having said that, little research has been accomplished around the premature mortality burden connected to pulmonary embolism in Cuba. Aims: To identify the premature mortality burden associated to pulmonary embolism in Cuba.international health estimates. Age- and BRPF2 Inhibitor Compound sex-specific YLL prices were calculated applying the Cuban mid-year population estimates as well as the agestandardized YLL rate (ASYR) was estimated by the direct technique employing the WHO’s standard population. Outcomes: A total of 2292 pulmonary embolism-related deaths had been identified, 1131 (49.3 ) male and 1161 (50.7 ) female. The median age at death in men was 75 years (interquartile range[IR]): 63 to 83) and in ladies 77 years (IR: 66 to 86). A total of 40 568 YLL have been accumulated, with an typical of 17.7 YLL per death. The absolute YLL count and crude YLL rate in accordance with age, sex and causes of death are shown in Figure 1 and Table 1. ASYR involving 2015 and 2018 elevated by 90.six in males (43 vs 82 YLL per one hundred 000 inhabitants) and by 52 in women (48 vs 73 YLL per one hundred 000 inhabitants).TABLE 1 YLL number and crude YLL rate because of premature mortality associated to pulmonary embolism by cause of death. Cuba, 2015Male Reason for death Pulmonary embolism Pulmonary embolism Acute embolism and thrombosis of specified or unspecified veins I26.x I82.2, I82.four, I82.six, I82.eight, I82.9 14 138 1400 0.63 0.06 11 990 1321 0.53 0.06 26 128 2721 0.58 0.06 ICD-10 codes YLL crudeYLL price Female YLL crudeYLL rate Total YLL crudeYLL rateABSTRACT877 of|Obstetric thromboembolism Limb vein thrombosis Deep vein thrombosis in pregnancy Deep vein thrombosis within the puerperium Phlebitis and thrombophlebitisO88.–0.0.O22.three O87.1 I80.x0.181 1440.01 0.01 0.181 144 one hundred.01 0.01 0.PB1195|Place and Burden of Extremity Vein Thrombosis in Patients with Solitary versus Numerous GSK-3 Inhibitor list Subsegmental Pulmonary Emboli R. Meverden1; Y. Hirao-Try1; D. Vlazny1; A. Casanegra1; D. Houghton1; D. Hodge2; L. Peterson1; R. McBane1; W. WysokinskiMayo Clinic, Rochester, Usa; 2Mayo Clinic, Jacksonville,Usa Background: Subsegmental pulmonary embolism (SSPE) is comparatively benign and may be managed with surveillance if bleeding threat is high and there are actually no other thromboses. SSPE could involve 1 or a lot more subsegmental branches. It remains unexplored if solitary versus several SSPE have substantial coexistence with upper and lower extremity deep vein thrombosis (DVT). Aims: The aim from the study was to evaluate the place and burden of DVT in upper and reduce extremities in solitary versus numerous SSPE. Approaches: Consecutive individuals with SSPE anticoagulated at Mayo FIGURE 1 Premature mortality associated to pulmonary embolism by age and sex. Cuba, 2015018 Conclusions: Premature mortality burden related to pulmonary embolism in Cuba is higher and appears to become rising, affecting far more males and also the elderly. Additional epidemiological analysis is required to enhance our understanding of this situation and its impactin our setting. Clinic Thrombophilia Clinic (03/01/20132/31/2020) had been followed prospectively. Outcomes: Out of 1542 patients with PE, 1317 patients had proximal PE and 225 (14.six ) SSPE, either solitary (n = 139) or various (n = 86; 47 with bilateral and 39 unilateral emboli). Of the proximal PE, 670 (50.9 ) had coexisting DVT in comparison with 68 (30.2 ) with SSPE (P 0.001). Proportion of sufferers with upper extremity DVT was not significantly distinct in solitary S