Caspase-3 activation in addition to a decreased quantity of TUNEL-positive cells. In addition, opening of mitochondrial KATP channels by POC might play a pivotalORIGINAL ARTICLEPostconditioning attenuates mitochondrial damagerole in preventing oxidative pressure and attenuating mtDNA damage in renal I/R IDO review injury. We conclude that POC might be a promising therapy for protection against I/R injury.AC K N O W L E D G E M E N T S This perform was supported by National Organic Science Foundation of China Award number 30900591 and Plan of New Century Excellent Talents of Ministry of Education in China, Award quantity NCET-10-0448.C O N F L I C T O F I N T E R E S T S TAT E M E N T None declared. (See associated short article by Moradi and Wang. Renoprotective mechanisms of ischemic postconditioning in ischemiareperfusion injury: enhanced mitochondrial function and integrity. Nephrol Dial Transplant 2013; 28: 2667669.)
HHS Public AccessAuthor manuscriptPLK4 Biological Activity nature. Author manuscript; obtainable in PMC 2014 April 17.Published in final edited form as: Nature. 2013 October 17; 502(7471): 37780. doi:10.1038/nature12508.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptA statin-dependent QTL for GATM expression is associated with statin-induced myopathyLara M. Mangravite1,, Barbara E. Engelhardt2,12,, Marisa W. Medina3, Joshua D. Smith4, Christopher D. Brown5, Daniel I. Chasman6, Brigham H. Mecham1, Bryan Howie2, Heejung Shim2, Devesh Naidoo3, QiPing Feng7, Mark J. Rieder4,13, Y-D I. Chen8, Jerome I. Rotter8, Paul M. Ridker6, Jemma C. Hopewell9, Sarah Parish9, Jane Armitage9, Rory Collins9, Russell A. Wilke7, Deborah A. Nickerson4, Matthew Stephens2,10,11, and Ronald M. Krauss3,1SageBionetworks, Seattle, Washington, USA of Human Genetics, University of Chicago, Chicago, Illinois, USA2Department 3Children’sHospital Oakland Analysis Institute, Oakland, California, USA of Genome Sciences, University of Washington, Seattle, Washington, USA of Genetics, University of Pennsylvania, Philadelphia, PA4Department 5Department 6Centerfor Cardiovascular Disease Prevention, Division of Preventative Medicine, Brigham and Women’s Hospital, Boston, MA7Departmentof Medicine, Division of Clinical Pharmacology, Vanderbilt University Healthcare Center, Nashville, TN, USA Genetics Institute, Cedars-Sinai, Los Angeles, CA8MedicalUsers might view, print, copy, and download text and data-mine the content material in such documents, for the purposes of academic analysis, topic often for the complete Circumstances of use:http://nature/authors/editorial_policies/license.html#terms Correspondence need to be addressed to: L.M.M. ([email protected]), M.S. ([email protected]), or R.M.K. ([email protected]). These authors contributed equally to this work. 11These authors co-directed this project. 12Current Address: Biostatistics and Bioinformatics Department and Division of Statistical Science, Duke University, Durham, NC, USA 13Current Address: Adaptive Biotechnologies, Seattle, WA, USA. Author Contributions L.M.M. created experiment and analyses, generated samples, performed analyses, and wrote the manuscript. B.E.E. made and performed analyses and wrote the manuscript. C.D.B. performed analyses of ENCODE data. B.H.M. designed and performed correlation analyses. J.D.S., M.J.R., and D.A.N. generated expression and genotype information. M.W.M. and D.N. made, performed and analyzed functional experiments. B.H. and H.S. developed and performed the imputation methodology, R.A.W, Q.F, J.D.S, M.J.R. and D.