Name : EPO, Human
Product Concentration :
Background :
Erythropoietin (EPO), a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells. The production of EPO by kidney cells is increased in response to hypoxia or anemia. Recombinant EPO has been approved for the treatment of anemia associated with chronic renal failure as well as for anemia of AZT treated AIDS patients.The cDNAs for EPO have been cloned from human, mouse, canine, etc. The mature proteins from the various species are highly conserved, exhibiting greater than 80% sequence identity at the amino acid level. Human EPO cDNA encodes a 193 amino acid residue precursor protein that is processed to yield a 165 amino acid residue mature protein. EPO contains one O-linked and three N-linked glycosylation sites. Glycosylation of EPO is required for EPO biological activities in vivo. EPO exhibits structural as well as amino sequence identity to the amino terminal 153 amino acid region of thrombopoietin.
Biological Activity :
EPO-alfa, Human (Cat. No. Z02975) stimulates cell proliferation of TF-1 cells. The ED50 for this effect is less than 1ng/mL. EPO, Human Erythropoietin (EPO), a glycoprotein produced primarily by the kidney, is the principal factor that regulates erythropoiesis by stimulating the proliferation and differentiation of erythroid progenitor cells. The production of EPO by kidney cells is increased in response to hypoxia or anemia. Recombinant EPO has been approved for the treatment of anemia associated with chronic renal failure as well as for anemia of AZT treated AIDS patients.The cDNAs for EPO have been cloned from human, mouse, canine, etc. The mature proteins from the various species are highly conserved, exhibiting greater than 80% sequence identity at the amino acid level. Human EPO cDNA encodes a 193 amino acid residue precursor protein that is processed to yield a 165 amino acid residue mature protein. EPO contains one O-linked and three N-linked glycosylation sites. Glycosylation of EPO is required for EPO biological activities in vivo. EPO exhibits structural as well as amino sequence identity to the amino terminal 153 amino acid region of thrombopoietin. .hide { display: none!important; } .product_table_cart_div{ width: 100%; } .product_table_cart_div .unit{ display: block; font-weight: bold; min-width: 120px; text-align: left; width: 100px; } .form-control{ width: 45px; height: 30px; line-height: 30px; display: inline; padding: 0px 0px 0px 5px; } .product_table_cart_div .size-box{ padding: 4px 5px; border: 1px solid #cccccc; text-align: center; margin-right: 10px; } .product_table_cart_div span{ color: black !important; } .product_table_cart_div .price{ font-weight: 600; font-style: normal; color: #1D73DD; font-size: 30px; text-align: left; color: #F41D27 !important; } .product_table_cart_div .price-td{ padding-bottom:50px !important; } .btn-add-to-cart .button-face{ height: 40px; font-size: 16px; } .size-list div{ display: inline-block; } .ask-us{ color: #1D73DD; margin: 0 10px; } .btn-add-to-cart{ width: 180px; }
expression system :
CHO
Tag :
EPO (Ala28-Arg193)Accession # P01588
Protein Accession No. :
P01588
Synonyms :
EPO-alpha; EPO alpha; EPO
Molecular Weight :
26~36 kDa, on SDS-PAGE under reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized after extensive dialysis against PBS.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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