Name : IL-1β, Mouse(CHO-expressed)
Product Concentration :
Background :
Interleukin-1 (IL-1) is a family of cytokines that play a central role in the regulation of immune and inflammatory responses to infections or sterile insults. IL-1α and IL-1β are the first two members discovered in this family, which are the products of distinct genes recognizing the same cell surface receptors. IL-1α and IL-1β are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The proteins are synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17.5 kDa. The specific protease responsible for the processing of IL-1β is interleukin 1β-converting enzyme (ICE)/caspase-1. Mature human and mouse IL-1β share approximately 75% amino acid sequence identity where human IL-1β has been found to be active on murine cell lines.
Biological Activity :
ED50 1.0 × 108 units/mg.
expression system :
CHO
Tag :
IL-1β (Val118-Ser269)Accession # P10749
Protein Accession No. :
P10749
Synonyms :
IL1B; IL-1; IL1-BETA; IL1F2; interleukin 1 beta; IL1beta
Molecular Weight :
~17.4 kDa, on SDS-PAGE under non-reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized after extensive dialysis against PBS.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
TGFBR2/TGF-beta RII Protein
TIM-3/HAVCR2 Protein
Popular categories:
IFN-lambda 2/IL-28A
Biliary Glycoprotein/CD66a