Name : PF-4/CXCL4, Human
Product Concentration :
Background :
Platelet factor 4, also known as CXCL4, is expressed in megakaryocytes and stored in the α-granules of platelets. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. Platelet factor 4 can be antiproliferative and antiangiogenic, at least in part via interfering with FGF2 and VEGF heparin binding and thus inhibiting their signaling. However, it can also be proinflammatory and proatherogenic through multiple effects on monocytes, macrophages and endothelial cells.
Biological Activity :
ED50
expression system :
HEK 293
Tag :
CXCL4 (Glu32-Ser101)Accession # P02776
Protein Accession No. :
P02776
Synonyms :
PF4; CXCL-4; SCYB4; Platelet Factor-4; Oncostatin A; Ironplact
Molecular Weight :
~7.8 kDa, on SDS-PAGE under non-reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized after extensive dialysis against PBS.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
Popular product recommendations:
HPD/HPPDase Protein
NRXN3/Neurexin-3 Protein
Popular categories:
Ubiquitin-Specific Peptidase 35
Fc epsilon RI