Name : Endostatin, Human
Product Concentration :
Background :
Endostatin is a cleaved product of the carboxyl-terminal domain of collagen XVIII. It functions as an anti-angiogenic cytokine that is expressed in various organs especially with high levels in liver, lung, and kidney. Endostatin inhibits angiogenesis by blocking the pro-angiogenic activities of VEGF and FGF-basic. In-vitro studies have shown endostatin blocks the proliferation and organization of endothelial cells into new blood vessels. In animal studies endostatin inhibited angiogenesis and growth of both primary tumors and secondary metastasis.
Biological Activity :
Determined by Endothelial Cell Tube Formation. The cells treated with 10 μg/ml Endostatin showed significant anti-angiogenesis effect.
expression system :
P. pastoris
Tag :
Endostatin (Ala1571-Lys1754)Accession # P39060
Protein Accession No. :
P39060
Synonyms :
Endostatin
Molecular Weight :
Purity :
> 97% as analyzed by SDS-PAGE
Product Concentration :
Expression System
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
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