Name : Noggin, Human(CHO-expressed)
Product Concentration :
Background :
Noggin, also known as NOG, is a homodimeric glycoprotein that bindsto and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors. Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients, regulating cellular responses dependent on the local concentration of the signaling molecule.
Biological Activity :
ED50
expression system :
CHO
Tag :
Noggin (Gln28-Cys232)Accession # Q13253
Protein Accession No. :
Q13253
Synonyms :
NOG; SYM1; SYNS1; SYNS1A; noggin
Molecular Weight :
29~31kDa, on SDS-PAGE under reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE
Product Concentration :
Lyophilized after extensive dialysis against PBS.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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