Name : sIL-6Rα, His, Human

Product Concentration :

Background :
Interleukin-6 Receptor (IL-6R) is a single trans-membrane protein that is the receptor for Interleukin-6 (IL-6). IL-6R forms a hexameric complex upon binding 2 molecules of IL-6 and two molecules of glycoprotein 130 (gp130) which activates intracellular JAK/STAT pathways. Although the normal form of IL-6R is the membrane-bound 80 kDa subunit, a soluble form of IL-6R (sIL-6R) can be generated physiologically by limited proteolysis or alternative splicing. sIL-6R binds to both IL-6 and gp130 generating intracellular signaling. In the immune system, sIL-6R is produced by both naïve and memory CD4 T-cells and strongly augments IL-6 ligand’s induction of Th-17 cells.

Biological Activity :
ED50 2.0 × 104 units/mg.

expression system :
Sf9 insect cells

Tag :
Expressed with an N-terminal Met. Poly-His sIL-6Rα (Leu20-Asp358)Accession # P08887-1 N-term C-term

Protein Accession No. :

Synonyms :
Interleukin-6 receptor subunit alpha; IL-6R subunit alpha; IL-6RA; IL-6R 1; Membrane glycoprotein 80; gp80; CD_antigen: CD126; sIL6RA

Molecular Weight :
~50 kDa, on SDS-PAGE under reducing conditions.

Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC

Product Concentration :
Lyophilized after extensive dialysis against PBS.

Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

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