Name : HVEM-Fc, Human
Product Concentration :
Background :
Herpes Virus Entry Mediator (HVEM) is a transmembrane protein that is the receptor for TNFSF14 (also known as LIGHT) and is therefore referred to asTNFRSF14. HVEM is expressed broadly on immune cells such as T cells, natural killer (NK) cells and monocytes. The interaction of 3 molecules of LIGHT with three molecules of HVEM forms a hexameric complex that leads to the recruitment and retention of effector cells and activates NK cells to produce large amounts of IFN-γ and GM-CSF. In addition to the canonical binding partner LIGHT, HVEM can also bind to the inhibitory signaling protein, B- and T- lymphocyte attenuator (BTLA), which suppresses immune responses. Therefore, the HVEM network plays an important role in regulating immunity and the behavior of lymphocytes.
Biological Activity :
Assay #1: ED50 1.0 × 104 units/mg.Assay #2: Immobilized HVEM, hFc, Human at 2.0 μg/ml (100 µl/well) can bind biotinylated human BTLA.Assay #3: Immobilized HVEM, hFc, Human at 2.0 μg/ml (100 µl/well) can bind biotinylated CD160, hFc, Human (Cat. No.: Z03449).
expression system :
Sf9 insect cells
Tag :
HVEM (Leu39-Lys184)Accession # Q92956 hFc N-term C-term
Protein Accession No. :
Q92956
Synonyms :
TNFRSF14; TR2
Molecular Weight :
~45 kDa, on SDS-PAGE under reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized after extensive dialysis against PBS.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
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