Name : LIX/CXCL5 (74aa), Mouse
Product Concentration :
Background :
Mouse LIX (C-X-C motif chemokine 5) is a small cytokine belonging to the CXC chemokine family that is cleaved into the following 2 chains [GCP-2(1-78) and GCP-2(9-78)]. Mouse LIX plays a role in reducing sensitivity to sunburn pain in some subjects, and is a potential target which could be used to understand more about pain in other inflammatory conditions. It is most closely related to two highly homologous human neutrophil chemoattractants GCP-2 and ENA-78. The first 78 amino acid residues within the predicted mature mouse LIX shares approximately 61% and 55% amino acid identity with human GCP-2 and ENA-78. This chemokine stimulates the chemotaxis of neutrophils possessing angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.
Biological Activity :
The EC50 value of mouse LIX/CXCL5 (74aa) on Ca2+ mobilization assay in CHO-K1/Gα15/mCXCR2 cells (human Gα15 and mouse CXCR2 stably expressed in CHO-K1 cells) is less than 200.0 ng/ml.
expression system :
HEK 293 Cells
Tag :
CXCL5 (Val45-Ala118)Accession # P50228
Protein Accession No. :
P50228
Synonyms :
C-X-C motif chemokine 5; Small-inducible cytokine B5; Cytokine LIX; Scyb5; GCP-2; Scyb6; ENA-78; AMCF-II; Epithelial Neutrophil Activating Peptide-78
Molecular Weight :
~8 kDa, on SDS-PAGE under reducing conditions.
Purity :
> 98% as analyzed by SDS-PAGE
Product Concentration :
Lyophilized after extensive dialysis against PBS.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
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