Name : IL-17F, Human
Product Concentration :
Background :
Human IL-17F is synthesized as a 153 aa precursor with a 20 aa signal sequence and a 133 aa mature region. Like IL-17A, IL-17F contains one potential site for N-linked glycosylation. IL-17A and IL-17F share 50% aa sequence identity. IL17-F homodimer is produced by an activated subset of CD4+ T cells, termed Th17. IL17-F has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.
Biological Activity :
Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 20.0 ng/ml, corresponding to a specific activity of > 5.0 × 104 IU/mg.
expression system :
E. coli
Tag :
Expressed with an N-terminal Met. IL-17F (Arg31-Gln163)Accession # Q96PD4
Protein Accession No. :
Q96PD4
Synonyms :
Interleukin-17F; IL17F
Molecular Weight :
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.2, with trehalose.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.
Related category websites: https://www.medchemexpress.com/recombinant-proteins.html
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