Name : SCF, Human (P. pastoris-expressed)

Product Concentration :

Background :
Stem cell factor (also known as SCF, KIT-ligand, KL, or steel factor) is a cytokine that binds to the c-KIT receptor (CD117). SCF can exist both as a transmembrane protein and a soluble protein. It stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors. SCF plays an important role in the hematopoiesis during embryonic development. SCF can regulates HSCs in the stem cell niche in the bone marrow. SCF has been shown to increase the survival of HSCs in vitro and contributes to the self-renewal and maintenance of HSCs in-vivo.

Biological Activity :
The ED50, as determined by the dose-dependent stimulation of human TF-1 cells, is 5 IU/mg.

expression system :
P. pastoris

Tag :
Expressed with an N-terminal Met. SCF (Glu26-Ala189)Accession # P21583-1

Protein Accession No. :

Synonyms :
Kit ligand; C-Kit Ligand; Mast Cell Growth Factor; MGF; Steel Factor; Stem cell factor

Molecular Weight :
~20 kDa, on SDS-PAGE under reducing conditions.

Purity :
> 95% as analyzed by SDS-PAGE

Product Concentration :
Lyophilized after extensive dialysis against 10 mM acetic acid.

Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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