Name : BD-3, Human
Product Concentration :
Background :
Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The α-defensins are distinguished from the β-defensins by the pairing of their three disulfide bonds. To date, four human β-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. β-defensins are expressed on some leukocytes and at epithelial surfaces. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The β-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1 (36 a.a.), a propeptide region. β-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. β-Defensins are 3-5 kDa peptides ranging in size from 33-47 amino acid residues.
Biological Activity :
Fully biologically active when compared to standard. The ED50 as determined by anti-microbial activity against E.coli is less than 30.0 μg/ml, corresponding to a specific activity of > 33.3 IU/mg.
expression system :
E. coli
Tag :
BD-3 (Gly23-Lys67)Accession # P81534
Protein Accession No. :
P81534
Synonyms :
Beta-defensin 103; Beta-defensin 3; DEFB-3; HBD3; hBD-3; Defensin, beta 103; Defensin-like protein; DEFB103A; BD3; DEFB103; DEFB3
Molecular Weight :
Purity :
> 98% as analyzed by SDS-PAGE> 98% as analyzed by HPLC
Product Concentration :
Lyophilized from a 0.2 μm filtered solution in 20 mM PBS, pH 7.4, 130 mM NaCl.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.
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