Name : IL-6, Mouse
Product Concentration :
Background :
Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that participates in both pro-inflammatory and anti-inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, and nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction and released into the blood stream to help break down fats and improve insulin resistance.
Biological Activity :
Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is less than 0.02 ng/ml, corresponding to a specific activity of > 5.0 × 107 IU/mg.
expression system :
E. coli
Tag :
Expressed with an N-terminal Met. IL-6 (Phe25-Thr211)Accession # P08505
Protein Accession No. :
P08505
Synonyms :
IL6; 26 kDa protein; IFN-β2; IFN-b2; B cell differentiation factor; BCDF; BSF-2; HPGF; HSF; MGI-2
Molecular Weight :
Purity :
> 97% as analyzed by SDS-PAGE> 97% as analyzed by HPLC
Product Concentration :
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.
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