Name : GRO-α/KC/CXCL1, Mouse

Product Concentration :

Background :
GRO-α/KC/CXCL1 coded by CXCL1 gene at chromosome 5 is approximately 63% identity to that of mouse MIP2. KC is also approximately 60% identical to the human GROs. Mouse KC is a potent neutrophil attractant and activator. The functional receptor for KC has been identified as CXCR2. Based on the pattern of KC expression in a number of inflammatory disease models, KC appears to have an important role in inflammation. KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease.

Biological Activity :
Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 10.0-100.0 ng/ml.

expression system :
E. coli

Tag :
GRO-α (Ala25-Lys96)Accession # P12850

Protein Accession No. :

Synonyms :
Growth Regulated Protein/Melanoma Growth Stimulatory Activity; GRO α; MGSA α; CXCL1; NAP-3; GRO1; KC (murine); CINC (rat)

Molecular Weight :

Purity :
> 97% as analyzed by SDS-PAGE> 97% as analyzed by HPLC

Product Concentration :
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.

Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.

MedChemExpress (MCE) recombinant proteins include: cytokines, enzymes, growth factors, hormones, receptors, transcription factors, antibody fragments, etc. They are often essential for supporting cell growth, stimulating cell signaling pathways, triggering or inhibiting cell differentiation; and are useful tools for elucidating protein structure and function, understanding disease onset and progression, and validating pharmaceutical targets. At MedChemExpress (MCE), we strive to provide products with only the highest quality. Protein identity, purity and biological activity are assured by our robust quality control and assurance procedures.
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