Name : M-CSF, Human
Product Concentration :
Background :
Macrophage-Colony Stimulating Factor (M-CSF), also known as Colony Stimulating Factor-1 (CSF-1), is a hematopoietic growth factor. It can stimulate the survival, proliferation and differentiation of mononuclear phagocytes, in addition to the spreading and motility of macrophages. In mammals, it exits three isoforms, which invariably share an N-terminal 32-aa signal peptide, a 149-residue growth factor domain, a 21-residue transmembrane region and a 37-aa cytoplasmictail. M-CSF is mainly produced by monocytes, macrophages, fibroblasts, and endothelial cells. M-CSF interaction with its receptor, c-fms, has been implicated in the growth, invasion, and metastasis of of several diseases, including breast and endometrial cancers. The biological activity of human M-CSF is maintained within the 149-aa growth factor domain, and it is only active in the disulfide-linked dimeric form, which is bonded at Cys63.
Biological Activity :
M-CSF, Human (Cat. No. Z02914) stimulates cell proliferation of M-NFS-60 cells. The ED50 for this effect is typically 1-3ng/mL. 2 μg of M-CSF, Human (Cat. No. Z02914) was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie Blue staining. Biological Activity M-CSF, Human (Cat. No. Z02914) stimulates cell proliferation of M-NFS-60 cells. The ED50 for this effect is typically 1-3ng/mL. 2 μg of M-CSF, Human (Cat. No. Z02914) was resolved with SDS-PAGE under reducing (R) and non-reducing (N) conditions and visualized by Coomassie Blue staining. Biological Activity M-CSF, Human (Cat. No. Z02914) stimulates cell proliferation of M-NFS-60 cells. The ED50 for this effect is typically 1-3ng/mL. M-CSF, Human Macrophage-Colony Stimulating Factor (M-CSF), also known as Colony Stimulating Factor-1 (CSF-1), is a hematopoietic growth factor. It can stimulate the survival, proliferation and differentiation of mononuclear phagocytes, in addition to the spreading and motility of macrophages. In mammals, it exits three isoforms, which invariably share an N-terminal 32-aa signal peptide, a 149-residue growth factor domain, a 21-residue transmembrane region and a 37-aa cytoplasmictail. M-CSF is mainly produced by monocytes, macrophages, fibroblasts, and endothelial cells. M-CSF interaction with its receptor, c-fms, has been implicated in the growth, invasion, and metastasis of of several diseases, including breast and endometrial cancers. The biological activity of human M-CSF is maintained within the 149-aa growth factor domain, and it is only active in the disulfide-linked dimeric form, which is bonded at Cys63. .hide { display: none!important; } .product_table_cart_div{ width: 100%; } .product_table_cart_div .unit{ display: block; font-weight: bold; min-width: 120px; text-align: left; width: 100px; } .form-control{ width: 45px; height: 30px; line-height: 30px; display: inline; padding: 0px 0px 0px 5px; } .product_table_cart_div .size-box{ padding: 4px 5px; border: 1px solid #cccccc; text-align: center; margin-right: 10px; } .product_table_cart_div span{ color: black !important; } .product_table_cart_div .price{ font-weight: 600; font-style: normal; color: #1D73DD; font-size: 30px; text-align: left; color: #F41D27 !important; } .product_table_cart_div .price-td{ padding-bottom:50px !important; } .btn-add-to-cart .button-face{ height: 40px; font-size: 16px; } .size-list div{ display: inline-block; } .ask-us{ color: #1D73DD; margin: 0 10px; } .btn-add-to-cart{ width: 180px; }
expression system :
E. coli
Tag :
Expressed with an N-terminal Met. M-CSF (Glu33-Ser190)Accession # P09603-3
Protein Accession No. :
P09603-3
Synonyms :
CSF1; CSF-1; MCSF; colony stimulating factor 1; Macrophage Colony Stimulating Factor; Lanimostim; MGC31930; MGI-IM
Molecular Weight :
~28 kDa, on SDS-PAGE under non-reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE
Product Concentration :
Lyophilized after extensive dialysis against 50 mM Tris-HCl, pH 8.0.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
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