Name : IL-15, Human
Product Concentration :
Background :
Interleukin-15 (IL-15) is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (among other cells) following infection by virus. This cytokine induces cell proliferation of natural killer cells, which are cells of the innate immune system whose principal role is to kill virally infected cells. IL-15 can stimulate the proliferation of T-lymphocytes. Stimulation by IL-15 occurs following its interaction with IL-15Rα. This interaction may enhance IL-15’s interaction with IL15Rβγc.
Biological Activity :
The ED50 as determined by the dose-dependant stimulation of the proliferation of CTLL-2 was found to be 2.0 × 106 IU/mg.
expression system :
E. coli
Tag :
IL-15 (Asn49-Ser162)Accession # P40933
Protein Accession No. :
P40933
Synonyms :
IL15; IL-T; interleukin 15
Molecular Weight :
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized after extensive dialysis against 20 mM PB, pH 7.5, 150 mM NaCl buffer.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. Avoid repeated freeze-thaw cycles.
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