Name : OSM (209aa), Human
Product Concentration :
Background :
Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor β or LIF Receptor β to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells.
Biological Activity :
ED50 1.0 × 105 units/mg.
expression system :
E. coli
Tag :
Expressed with an N-terminal Met. OSM (Ala26-Arg234)Accession # P13725
Protein Accession No. :
P13725
Synonyms :
OncoM; oncostatin M
Molecular Weight :
~23.8 kDa, on SDS-PAGE under reducing conditions.
Purity :
> 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
Product Concentration :
Lyophilized after extensive dialysis against PBS.
Storage and Stability :
Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
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